Archive for the 'Bioinformatics' Category



Inflammatory Breast Cancer: A Complex Disease

This article reviews the following: “Molecular Determinants of the Inflammatory Breast Cancer Phenotype”.

Tags: aggressive disease, breast cancers, breast tumor, cancer phenotype, clinical criteria, existing research, gtpase, her2 neu, houchens, inflammatory breast cancer, molecular determinants, multidisciplinary approach, preoperative chemotherapy, radiation therapy, subtype, survival rates, systemic chemotherapy, tannenbaum

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Molecular Determinants Of The Inflammatory [...]

Gene Therapy Reversed Heart Damage In Heart Failure

Long-term gene therapy resulted in improved cardiac function and reversed deterioration of the heart in rats with heart failure, according to a recent study conducted by researchers at Thomas Jefferson University’s Center for Translational Medicine. The study was published online in Circulation.

Tags: adrenergic receptors, beta blocker, cardiac function, desensitization, downward slope, [...]

New Congenital Neutropenia Syndrome And Causative Gene Mutation Identified By Scientists

A team of scientists has discovered a new syndrome associated with severe congenital neutropenia (SCN), a rare disorder in which children lack sufficient infection-fighting white cells, and identified the genetic cause of the syndrome: mutations in the gene Glucose-6-phosphatase, catalytic subunit 3 (G6PC3). The findings, which are published in the Jan. 1, 2009 issue of [...]

Toxicity Mechanism Identified For Parkinson’s Disease

Neurologists have observed for decades that Lewy bodies, clumps of aggregated proteins inside cells, appear in the brains of patients with Parkinson’s disease and other neurodegenerative diseases.
The presence of Lewy bodies suggests underlying problems in protein recycling and waste disposal, leading to the puzzle: how does disrupting those processes kill brain cells?

[...]

Parkinson’s Disease Plays Havoc With Common Orthopaedic Conditions

Although Parkinson’s disease (PD) is a neurological disorder, according to an article in the January 2009 issue of the Journal of the American Academy of Orthopaedic Surgeons,
the disease also increases a person’s risk of experiencing complicated
orthopaedic conditions. The author recommends that all Parkinson’s
treatment plans include a multidisciplinary approach in order to
address additional accompanying musculoskeletal health [...]